Histological Changes in Cerebral Abteries With Increasing Age

Q: What is the clinical evidence from this study?

Study design: Review. Population: Cerebral small vessel disease (SVD).

Q: What does this research mean for the field?

Inflammation, chronic hypoperfusion, oxidative damage, glymphatic alterations, and blood-brain barrier disruption are key contributors to the pathogenesis of cerebral small vessel disease. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Arthur C. Klassen; Joo Ho Sung; Emanuel M. Stadlan

doi:10.1097/00005072-196810000-00006

October 1, 1968Journal of Neuropathology & Experimental Neurology

Histological Changes in Cerebral Abteries With Increasing Age

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Why the study?

The pathophysiology of cerebral small vessel disease and its contribution to vascular cognitive impairment and dementia remain incompletely understood, requiring further investigation of inflammatory and vascular mechanisms.

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Population

Cerebral small vessel disease (SVD)

Limitations

Use of different animal models may not represent a constant level of clinical reversibility.
Available results are often based on relatively small sample sizes.
Correlation between different techniques and the anatomical distribution and severity of vascular lesions has rarely been systematically investigated.
Results reflect global biochemical changes rather than single disease markers and often lack specific clinical information.

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Abstract

Arthur C. Klassen, M.D., Joo Ho Sung, M.D., Emanuel M. Stadlan, M.D.; Histological Changes in Cerebral Arteries with Increasing Age*†‡, Journal of Neuropat

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Cite This Study

Klassen et al. (1968) conducted a review in Cerebral small vessel disease (SVD).

synapsesocial.com/papers/6ace3684ac3279232f507bb1 https://doi.org/10.1097/00005072-196810000-00006

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Histological Changes in Cerebral Abteries With Increasing Age

PICO

Limitations

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Abstract

Discussion

Cite This Study

Histological Changes in Cerebral Abteries With Increasing Age

PICO

Limitations

Ask about this paper

Abstract

Discussion

Cite This Study

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