Key result
Severe renal vascular lesions link to ~2.9-point higher E/e′ in diabetic nephropathy.
Why the study?
The association between renal vascular lesion severity and echocardiographic indices related to diastolic function in diabetic nephropathy remains unclear.
Cross-Sectional (n=360)
No
Mean Difference: 2.91 (95% CI 0.969–4.851)
Absolute Event Rate: 13% vs 9.3%
p-value: p=<0.01
In patients with diabetic nephropathy, more severe biopsy-proven renal vascular lesions are independently associated with echocardiographic signs of worse diastolic function, illustrating a direct link between renal microvascular damage and adverse cardiac remodeling.
Does not support practice change in diabetic nephropathy; extends observational links between renal vascular lesions and diastolic dysfunction, warranting longitudinal studies.
AIMS: Renal vascular lesions are common in diabetic nephropathy (DN), but their association with echocardiographic indices related to diastolic function remains unclear. This study investigated the relationship between renal vascular lesion severity and echocardiographic indices in biopsy-confirmed DN. METHODS: This biopsy-based cross-sectional study included 360 patients with biopsy-confirmed DN and available echocardiographic data. Renal vascular lesions were evaluated using a composite score of arteriolar hyalinosis and arteriosclerosis, and patients were categorized into three severity groups (scores 0-1, 2-3, and 4). Echocardiographic indices included E/e', e', and left atrial diameter (LA). Multivariable linear regression models were used to assess the associations between renal vascular lesion severity and echocardiographic parameters. Sensitivity analyses were performed using continuous vascular lesion scores and additional covariate adjustment. RESULTS: Among 360 patients, 53, 253, and 54 were classified into the 0-1, 2-3, and 4 score groups, respectively. Compared with the 0-1 group, moderate and severe vascular lesions were associated with higher E/e' (β = 1.814 and 2.910, respectively) and larger LA (β = 1.722 and 2.917, respectively) after multivariable adjustment. Continuous score analysis showed that each 1-point increase in vascular lesion score was associated with higher E/e', larger LA, and lower e'. Associations with E/e' and LA were generally consistent across sensitivity analyses, whereas the association with e' was less stable. CONCLUSIONS: In patients with biopsy-confirmed DN, greater renal vascular lesion severity was associated with higher E/e' and larger LA, highlighting a potential link between renal vascular pathology and echocardiographic indices related to diastolic function.
No takes yet. Share an insight, caveat, or question.
Wang et al. (2026) conducted a cross-sectional in Diabetic Nephropathy (n=360). Severe renal vascular lesions (composite score 4) vs. Mild renal vascular lesions (composite score 0-1) was evaluated on E/e′ ratio (index of left-ventricular filling pressure) (MD 2.910, 95% CI 0.969 to 4.851, p=<0.01). In patients with biopsy-confirmed diabetic nephropathy, severe renal vascular lesions were significantly associated with a higher E/e′ ratio (adjusted mean difference 2.91) compared to mild lesions.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: