Қорақалпоғистон Республикаси аҳолиси ўртасида юрак ишемик касаллигини эрта ташхислашда липидлар профилининг прогностик аҳамияти

Q: What are the key findings of this study?

Elevated LDL-C was the strongest independent predictor of early coronary heart disease (OR 2.84), showing high discriminative capacity (AUC = 0.86).

Q: What is the clinical evidence from this study?

Study design: Case-Control. Population: Early-stage coronary heart disease (n=220). Intervention: Elevated low-density lipoprotein cholesterol (LDL-C) vs. Healthy controls / lower LDL-C levels. Primary outcome: Early-stage coronary heart disease prediction (OR 2.84, 95% CI 1.92-4.21, p=<0.001).

Q: What does this research mean for the field?

Elevated low-density lipoprotein cholesterol (LDL-C) is the strongest independent predictor of early coronary heart disease (OR 2.84, AUC = 0.86) in the population of Karakalpakstan. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

Determine the prognostic value of lipid profile parameters for early detection and risk stratification of coronary heart disease.

Эльмира Кеулимжаева; Khurshid Ataniyazov; Эльмира Кеулимжаева; Khurshid Ataniyazov; Elmira Keulimjaeva; Khurshid Ataniyazov

doi:10.47689/2181-3663-vol5-iss1-pp484-489

January 20, 2026Профилактическая медицина и здоровьеOpen Access

Қорақалпоғистон Республикаси аҳолиси ўртасида юрак ишемик касаллигини эрта ташхислашда липидлар профилининг прогностик аҳамияти

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Key result

Elevated LDL-C is linked to ~2.8-fold higher odds of early coronary heart disease.

OR 2.84
95% CI 1.92-4.21
P<0.001
n=220

Why the study?

Lipid imbalance and its prognostic value for early coronary heart disease risk stratification in the population of the Republic of Karakalpakstan were not well characterized.

Key Points

Determine the prognostic value of lipid profile parameters for early detection and risk stratification of coronary heart disease.
Assessed 220 participants aged 40–70 years divided into 110 patients with clinically verified early-stage coronary heart disease and 110 control individuals without cardiovascular pathology.
Measured total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides using standardized enzymatic methods.
Evaluated lipid distribution patterns and predictive capacity using independent samples t-tests, multivariate logistic regression, and receiver operating characteristic (ROC) curve modeling.
Patients with early coronary heart disease had significantly higher mean total cholesterol (6.42 ± 0.81 vs 4.98 ± 0.67 mmol/L), LDL-C (4.11 ± 0.72 vs 2.89 ± 0.54 mmol/L), and triglycerides (2.21 ± 0.63 vs 1.39 ± 0.48 mmol/L), and lower HDL-C (1.02 ± 0.21 vs 1.36 ± 0.27 mmol/L; all p < 0.001).
Multivariate logistic regression identified LDL-C as the strongest independent predictor of early disease (OR = 2.84, 95% CI 1.92–4.21, p < 0.001), alongside total cholesterol (OR = 1.97, 95% CI 1.41–2.75, p < 0.001) and triglycerides (OR = 1.68, 95% CI 1.22–2.33, p = 0.002), whereas HDL-C was protective (OR = 0.54, 95% CI 0.39–0.75, p < 0.001).
ROC analysis showed high discriminative capacity for LDL-C alone (AUC = 0.86), while combining multiple lipid abnormalities increased overall predictive accuracy to an AUC of 0.89.

Study Design

Type

Case-Control (n=220)

Multicenter

No

Structured PICO

P

Population

220 adults aged 40-70 years from the Republic of Karakalpakstan, comprising 110 patients with early-stage coronary heart disease and 110 healthy controls, evaluated for lipid profile abnormalities.

O

Outcome

Presence of early-stage coronary heart disease (predicted by lipid profile parameters)

Main Result

Odds Ratio: 2.84 (95% CI 1.92–4.21)

p-value: p=<0.001

Elevated LDL-C and triglycerides along with reduced HDL-C are strong independent predictors of early coronary heart disease in the population of the Aral Sea region, confirming the utility of routine lipid screening.

Implication

Supports LDL-C screening in this population; hypothesis-generating and requires prospective validation before changing practice.

Abstract

Lipid imbalance contributes significantly to early coronary heart disease formation in the population of the Republic of Karakalpakstan. It was established that there were statistically higher levels of total cholesterol, low-density lipoprotein cholesterol, and triglycerides in patients with early coronary involvement. It was determined that reduced high-density lipoprotein cholesterol increases atherogenic risk. The impact of lipid parameters on coronary risk was evaluated using logistic regression and ROC analysis. Distribution patterns of lipid fractions across clinical groups were characterized. The prognostic value of combined lipid abnormalities for early cardiovascular risk stratification was considered.

Discussion

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Cite This Study

Кеулимжаева et al. (2026) conducted a case-control in Early-stage coronary heart disease (n=220). Elevated low-density lipoprotein cholesterol (LDL-C) vs. Healthy controls / lower LDL-C levels was evaluated on Early-stage coronary heart disease prediction (OR 2.84, 95% CI 1.92-4.21, p=<0.001). Elevated LDL-C was the strongest independent predictor of early coronary heart disease (OR 2.84), showing high discriminative capacity (AUC = 0.86).

synapsesocial.com/papers/6ace6de6b52af824ab02bbb2 https://doi.org/10.47689/2181-3663-vol5-iss1-pp484-489

Topics

Coronary artery disease

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Қорақалпоғистон Республикаси аҳолиси ўртасида юрак ишемик касаллигини эрта ташхислашда липидлар профилининг прогностик аҳамияти

Key Points

Study Design

Structured PICO

Main Result

Implication

Abstract

Discussion

Cite This Study

Topics

Қорақалпоғистон Республикаси аҳолиси ўртасида юрак ишемик касаллигини эрта ташхислашда липидлар профилининг прогностик аҳамияти

Key Points

Study Design

Structured PICO

Main Result

Implication

Abstract

Discussion

Cite This Study

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Topics

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