The major polyene antibiotic macrolide isolated from Streptomyces filipinensis, filipin III, was reinvestigated in DMSO solution using homonuclear and heteronuclear correlation spectroscopy. In addition to several corrections to previous 1H NMR assignments, the nine exchangeable hydroxylic protons were structure-specifically assigned together with 13C NMR lines using proton-detected HSQC spectroscopy. The magnitudes of the 3J proton–proton couplings indicated a probable constrained geometry of the macrocyclic lactone.
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Rochet et al. (1997) studied this question.
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