Concept of organ dysfunction revealed by shift in thinking from V = IR to W = VI

Blood pressure is expressed as V (blood pressure) = I (circulating blood volume or cardiac output) × R (peripheral vascular resistance), based on Ohm’s law (V (voltage) = I (current) × R (resistance)). Antihypertensive drugs that reduce either I or R are used. On the other hand, the electrical energy consumed per unit time is power (W), which is expressed as W = VI. If we consider the energy consumed by each organ to be W, and assume that an organ consumes a constant amount of functional bioenergy requirement (FBR), then V and I work in a complementary manner. It is conceivable that if a decrease in blood flow occurs first due to conditions such as arteriosclerosis or peripheral circulatory failure, peripheral blood pressure will rise compensatorily; conversely, if systemic blood pressure rises first, tissue blood flow will decrease compensatorily, potentially leading to chronic ischemia. In this medical hypothesis, I would like to consider a shift in perspective from V = IR to W = VI in blood pressure management—a field that has traditionally focused on peripheral vascular resistance (R)—by shifting the focus to blood pressure regulation aimed at maintaining FBR in tissues.