Key result
EGSYS score predicts cardiac syncope with ~0.82 AUC, optimized at a cutoff of 3.
Why the study?
EGSYS score was designed to differentiate cardiac from noncardiac causes of syncope, but its accuracy required validation in syncope patients referred to the emergency department.
Cross-Sectional (n=198)
Yes
Effect estimate: AUC 0.818 for EGSYS-U (95% CI 0.75-0.87)
Supports EGSYS ≥3 for ED syncope triage; extends prior validation to new populations but leaves outcome impact open.
Introduction. Evaluation of Guidelines in Syncope Study (EGSYS) is designed to differentiate between cardiac and noncardiac causes of syncope. The present study aimed to evaluate the accuracy of this predictive model. Methods. In this prospective cross-sectional study, screening performance characteristics of EGSYS-U (univariate) and EGSYS-M (multivariate) in prediction of cardiac syncope were calculated for syncope patients who were referred to the emergency department (ED). Results. 198 patients with mean age of 59.26 ± 19.5 years were evaluated (62.3% male). 115 (58.4%) patients were diagnosed with cardiac syncope. Area under the ROC curve was 0.818 (95% CI: 0.75-0.87) for EGSYS-U and 0.805 (CI 95%: 0.74-0.86) for EGSYS-M (p = 0.53). Best cut-off point for both models was ≥3. Sensitivity and specificity were 86.08% (95% CI: 78.09-91.59) and 68.29% (95% CI: 56.97-77.86) for EGSYS-U and 91.30% (95% CI: 84.20-95.52) and 57.32% (95% CI: 45.92-68.02) for EGSYS-M, respectively. Conclusion. The results of this study demonstrated the acceptable accuracy of EGSYS score in predicting cardiogenic causes of syncope at the ≥3 cut-off point. It seems that using this model in daily practice can help physicians select at risk patients and properly triage them.
No takes yet. Share an insight, caveat, or question.
Kariman et al. (2015) conducted a cross-sectional in Syncope (n=198). EGSYS score was evaluated on Area under the ROC curve for prediction of cardiac syncope (AUC 0.818 for EGSYS-U, 95% CI 0.75-0.87). The EGSYS score accurately predicted cardiogenic causes of syncope with an area under the ROC curve of 0.818 for the univariate model, achieving optimal sensitivity and specificity at a cut-off of ≥3.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: