Key result
Proteomics reveals ~6- to 7-fold more distinct proteins than genes in the human genome.
Why the study?
The genome-centric view of human biology is limited because the number of genes does not fully explain biological diversity and complexity, highlighting the importance of studying proteins.
Design
Review
Supports proteomic integration in cardiovascular research; challenges genomic sufficiency and leaves open clinical translation.
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Joseph Loscalzo (2003) reported a review. Proteomics reveals that there are approximately 6 to 7 times as many distinct proteins as the roughly 30,000 genes in the human genome, defining biological form and function.
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