Key result
Restrictive transfusion shows no significant benefit over a liberal strategy for death or MI.
Why the study?
The optimal hemoglobin threshold for blood transfusion in patients with acute myocardial infarction and anemia remains uncertain.
Does a restrictive transfusion strategy reduce 6-month mortality compared to a liberal strategy in patients with acute myocardial infarction and anemia?
RCT (n=3,504)
Open-label
randomly assigned
Yes
Does a restrictive transfusion strategy reduce 6-month mortality compared to a liberal strategy in patients with acute myocardial infarction and anemia?
Answers are grounded in this paper and cite their sources.
A restrictive transfusion strategy did not significantly affect overall 6-month mortality compared to a liberal strategy in acute MI patients with anemia, but it was associated with an increased risk of cardiac death.
International audience
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Simon et al. (2024) conducted an RCT in Acute myocardial infarction and anemia (n=3,504). Restrictive transfusion strategy vs. Liberal transfusion strategy (transfusion when hemoglobin ≤10 g/dL) was evaluated on Composite of death or non-fatal MI at 30 days (RR 1.15, 95% CI 0.99-1.34, p=0.07). A restrictive transfusion strategy resulted in a non-significant numerical increase in the 30-day primary composite of death or non-fatal MI (16.9% vs 14.5%, RR 1.15, p=0.07) and similar 6-month all-cause mortality compared to a liberal strategy.
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