Key result
HHV-6 infection during pediatric immunosuppression is linked to rapid and fatal myocarditis.
Why the study?
Fatal myocarditis is a rare complication in immunosuppressed children and recent reports have linked HHV-6 infection with myocarditis in this population.
Case Report (n=2)
Answers are grounded in this paper and cite their sources.
Supports vigilance for HHV-6 in immunosuppressed children with myocarditis; leaves open need for prospective studies before screening or therapy changes.
Fatal myocarditis is a rare complication in immunosuppressed children. Recent reports have linked human herpesvirus 6 (HHV-6) infection, typically a benign infection in childhood, with myocarditis. HHV-6 can reactivate during periods of immunosuppression. Here, we report 2 cases in which children were immunosuppressed, one for treatment of Evans syndrome and the other post hematopoietic stem cell transplantation, who developed rapid and fatal HHV-6-associated myocarditis. These cases suggest that HHV-6 infection should be considered as an etiology of myocarditis in immunosuppressed patients regardless of correlating blood levels. Early treatment of HHV-6 in patients with myocarditis could improve morbidity and mortality.
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Stefanski et al. (2015) conducted a case report in HHV-6-associated myocarditis (n=2). HHV-6 infection during immunosuppression was evaluated on Fatal myocarditis. Human herpesvirus 6 (HHV-6) infection or reactivation during periods of immunosuppression was associated with rapid and fatal myocarditis in two pediatric cases.
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