Why the study?
The source of spontaneous initiation of ventricular fibrillation has not been mapped.
Does radiofrequency ablation of mapped triggers prevent recurrence of ventricular fibrillation in patients with idiopathic ventricular fibrillation?
Observational (n=16)
Does radiofrequency ablation of mapped triggers prevent recurrence of ventricular fibrillation in patients with idiopathic ventricular fibrillation?
Radiofrequency ablation targeting triggers in the Purkinje system or myocardium can successfully eliminate the initiation of recurrent idiopathic ventricular fibrillation.
Ventricular fibrillation is the main mechanism of sudden cardiac death, but the source of its spontaneous initiation has not been mapped. 16 patients were investigated by electrography and radiofrequency ablation after resuscitation from recurrent idiopathic ventricular fibrillation. Triggers of ventricular fibrillation originated from various locations within the Purkinje system in 12 patients and from the ordinary myocardial muscle in four. The accuracy of mapping was confirmed by acute elimination of triggers by radiofrequency delivery, and there was no recurrence of ventricular fibrillation in 14 patients. Long-term follow-up is necessary to establish that ablation is curative and avoids use of a defibrillator.
No takes yet. Share an insight, caveat, or question.
Haı̈ssaguerre et al. (2002) conducted an observational in recurrent idiopathic ventricular fibrillation (n=16). Electrography mapping and radiofrequency ablation was evaluated on no recurrence of ventricular fibrillation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: