Alcohol Liver Pathology Signature: A Composite Histological Pattern for Differentiating Alcohol–associated Liver Disease from Metabolic Dysfunction–associated Steatotic Liver Disease

Metabolic dysfunction–associated steatotic liver disease (MASLD) and alcohol–associated liver disease (ALD) are leading causes of chronic liver injury with overlapping clinical and histological presentations. This study evaluated a composite histologic pattern, termed the Alcohol Liver Pathology Signature (ALPS), for potential use in the differential diagnosis of ALD and MASLD and to explore potential clinical and demographic correlates.