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October 13, 2026Science Signaling

Shutting down GPCRs

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Abstract

Bifunctional antibodies linking a GPCR with the transferrin receptor lead to GPCR down-regulation.

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John F. Foley (2026) studied this question.

synapsesocial.com/papers/6ad06d090baecf8d117b984f https://doi.org/10.1126/scisignal.aem9378

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1GPCR antagonism via rewiring of receptor trafficking and degradationOriginal Research · 2026 · 1 citations
2GPCR Antagonism via Antibody-Mediated Rewiring of Receptor Trafficking and Degradation2025 · 2 citations
3A GPCR-G protein-β-arrestin megacomplex enabled by a versatile allosteric modulatorpreclinical · 2026 · 7 citations
4Altered Intracellular Trafficking as a Mechanism for Prolonged Duration of G Protein-Coupled Receptor ActivationOriginal Research · 2026
5Abstract 4712: GPCR panel establishment and application in drug discovery2024

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