Downregulation of RRS1 Inhibits Proliferation, Migration, And Epithelial-Mesenchymal Transition In Hepatocellular Carcinoma

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Background: Regulator of ribosome rynthesis 1 (RRS1) is an important nuclear protein involved in the biogenesis of ribosomes, and its relationship with a variety of cancers is confirmed by several studies. However, the underlying mechanism of RRS1-related carcinogenesis remains largely elusive.Methods: In this study, we aimed to investigated the role of RRS1 in hepatocellular carcinoma (HCC) by detecting the expression level of RRS1 in HCC tissues and para-carcinoma tissues and its effect on the proliferation, migration and epithelial-mesenchymal transition of HCC. Results: Compared with para-carcinoma tissues, the expression of RRS1 was significantly higher in HCC tissues, which is associated with the poor prognosis for HCC patients. In addition, knockdown RRS1 in HCC cell lines inhibited proliferation, migration and epithelial-mesenchymal transition (EMT). Conclusions: Our results indicated that RRS1 played an important role in proliferation, migration and EMT process of HCC. Hence, RRS1 might emerge as a promising therapeutic target for HCC.