Key result
South Asian ethnicity linked to ~0.2% higher HbA1c compared with White European ethnicity.
Why the study?
HbA1c levels are higher in most ethnic groups compared with white Europeans independent of glycemic control, but this comparison has not been performed between South Asians and white Europeans.
Are HbA1c, fasting plasma glucose, and 2-h plasma glucose levels higher in South Asians compared to White Europeans independent of glycemic control?
Cross-Sectional (n=6,040)
Are HbA1c, fasting plasma glucose, and 2-h plasma glucose levels higher in South Asians compared to White Europeans independent of glycemic control?
Answers are grounded in this paper and cite their sources.
South Asian ethnicity is independently associated with higher HbA1c and plasma glucose levels compared to White Europeans, suggesting ethnic-specific differences in glycemia beyond typical risk factors.
OBJECTIVE HbA1c levels are higher in most ethnic groups compared with white Europeans (WEs) independent of glycemic control. This comparison has not been performed between South Asians (SAs) and WEs. We analyzed the independent effect of ethnicity on HbA1c and fasting and 2-h plasma glucose (FPG and 2hrPG, respectively) between these groups. RESEARCH DESIGN AND METHODS Analysis of the ADDITION-Leicester study, in which 4,688 WEs and 1,352 SAs underwent oral glucose tolerance testing, HbA1c, and other risk factor measurements. RESULTS Significant associations with HbA1c included ethnicity, FPG, 2hrPG, and homeostasis model assessment of β-cell function (P < 0.001); age and sex (P < 0.01); and fasting insulin and potassium (P < 0.05). After adjusting for these and other risk factors, SAs demonstrated higher HbA1c (6.22 and 6.02%, mean difference 0.20%, 0.10–0.30, P < 0.001), FPG (5.15 and 5.30 mmol/L, mean difference 0.15 mmol/L, 0.09–0.21, P < 0.001), and 2hrPG (5.82 and 6.57 mmol/L, mean difference 0.75 mmol/L, 0.59–0.92, P < 0.001) compared with WEs, respectively. CONCLUSIONS HbA1c, FPG, and 2hrPG levels were higher in SAs independent of factors affecting glycemic control.
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Mostafa et al. (2012) conducted a cross-sectional in Glycemia (n=6,040). South Asian ethnicity vs. White European ethnicity was evaluated on HbA1c levels (MD 0.20%, 95% CI 0.10-0.30, p=<0.001). South Asian ethnicity was independently associated with higher HbA1c compared with White European ethnicity (6.22% vs 6.02%; mean difference 0.20%, 95% CI 0.10-0.30; P<0.001).
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