Key result
New protocol maps cardiovascular risk prediction models developed for adults with serious mental illness.
Why the study?
Commonly used cardiovascular and cardiometabolic risk-prediction models were largely developed in general-population cohorts and may not adequately account for factors specific to adults with serious mental illness.
This scoping review aims to map and evaluate cardiovascular and cardiometabolic prediction models specifically for adults with serious mental illness to identify gaps for future clinical application.
Highlights absence of SMI-specific cardiovascular prediction models; leaves open targeted validation studies before clinical adoption.
Adults with serious mental illness, particularly schizophrenia spectrum disorders, schizoaffective disorder, and bipolar disorder, experience a disproportionately high burden of cardiovascular and cardiometabolic morbidity and premature mortality. However, commonly used risk-prediction models were largely developed in general-population cohorts and may not adequately account for factors specific to serious mental illness. This scoping review will map cardiovascular and cardiometabolic prediction models developed, validated, updated, or evaluated in adults with serious mental illness; summarize their populations, predictors, modelling approaches, and reported performance; and identify gaps relevant to future model development, validation, and clinical application.
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Lee et al. (2026) conducted a review in Serious mental illness. Cardiovascular and cardiometabolic prediction models vs. General-population risk-prediction models was evaluated. This scoping review outlines a protocol to map and evaluate cardiovascular and cardiometabolic prediction models developed or validated in adults with serious mental illness.
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