Key result
Monotherapy accounts for ~61% of outpatient hypertension prescriptions, led predominantly by amlodipine.
Why the study?
Appropriate hypertension management in Prolanis patients is crucial to control blood pressure and prevent long-term cardiovascular complications, but prescribing patterns were not evaluated.
Cross-Sectional (n=832)
No
Real-world prescribing patterns align well with national guidelines through high utilization of amlodipine and amlodipine-lisinopril combinations, though there is a need to optimize the early initiation of dual therapy in the productive-age group.
Appropriate hypertension management in Chronic Disease Management Program (Prolanis) patients is crucial to control blood pressure and prevent long-term cardiovascular complications. This study aimed to evaluate the prescribing pattern of antihypertensive drugs in Prolanis patients in outpatient clinics. This descriptive observational study with a cross-sectional design analyzed prescription data from 832 hypertensive patients who met the inclusion criteria. The majority of patients were women (80.60%) with the largest age group being in the range of 41–59 years (61.10%) and age ≥60 years (31.10%). The prescribing pattern was dominated by monotherapy at 60.5% (n = 503), which massively used Calcium Channel Blocker (CCB) in the form of Amlodipine (96.8% of total monotherapy). Two-drug combination therapy was administered to 38.5% of patients (n = 320), with CCB + ACE Inhibitor (Amlodipine + Lisinopril) regimen as the most dominant choice (83.4%). Three-drug combination therapy was very rare (1.1%), but noted a minor polypharmacy anomaly in the form of duplication of Amlodipine preparation therapy. The antihypertensive prescribing pattern in Prolanis patients was largely in line with national and international clinical guidelines through the selection of Amlodipine and the effective combination of Amlodipine-Lisinopril. However, optimization of early initiation of two-drug combination therapy for productive age and supervision of rational prescribing need to be improved to ensure patient safety.
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Fatharony et al. (2026) conducted a cross-sectional in Hypertension (n=832). Antihypertensive medications was evaluated on Antihypertensive prescribing pattern. Among 832 hypertensive outpatients, antihypertensive prescriptions were dominated by monotherapy (60.5%, predominantly amlodipine) and two-drug combinations (38.5%, mostly amlodipine-lisinopril).
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