Clinical Determinants of In-Hospital Mortality in a Multicenter Coronary Care Unit Cohort

Background: Cardiovascular diseases remain a major global health concern, and coronary care units (CCUs) provide specialized care for patients with acute cardiovascular conditions.Aim: This multicenter cohort study aimed to investigate mortality rates in Turkish CCUs and identify predictors of in-hospital mortality. Study Design:The MORCOR-TURK study was designed as a prospective, national, multicenter, observational cohort study.Methods: Patients admitted to CCUs across Türkiye with cardiovascular diagnoses were included.Demographic, clinical, laboratory, and outcome data were collected.Regression analyses were performed to identify predictors of in-hospital mortality.Results: A total of 3,157 patients were included, and the overall CCU mortality rate was 4.3% (n=137).The median age was 65 years (interquartile range, 56-73), and 66.1% of the patients were male.Hypertension (59.8%) and diabetes mellitus (37.5%) were the most common comorbidities.Non-survivors had significantly higher rates of heart failure and chronic kidney disease and lower ejection fractions than survivors.Age, female sex, lower mean blood pressure (BP), elevated serum creatinine, C-reactive protein, and white blood cell count were independent predictors of in-hospital mortality.Mean BP and serum creatinine were the strongest contributors to mortality prediction.Conclusion: CCU mortality in Türkiye was relatively low.Hemodynamic impairment and renal dysfunction were the primary determinants of in-hospital mortality, highlighting the value of simple clinical parameters for early risk stratification.