Key result
Meta-analysis investigates the association between omega-3 fatty acid supplementation and incident atrial fibrillation risk.
Why the study?
Uncertainty remains regarding the safety of omega-3 dietary supplements and their association with incident atrial fibrillation risk.
Does omega-3 dietary supplementation affect the risk of incident atrial fibrillation?
Meta-Analysis (n=25,692)
Does omega-3 dietary supplementation affect the risk of incident atrial fibrillation?
This meta-analysis of 18 trials investigates whether omega-3 dietary supplementation is associated with an increased risk of incident atrial fibrillation.
Distinguishes AF risk with dietary supplements from high-dose prescription omega-3; extends prior evidence to non-prescription formulations.
Objectives: Our recent meta-analysis suggested that atrial fibrillation (AF) risk increased with omega-3 (EPA+DHA) treatment only in high cardiovascular (CV) disease–risk populations receiving high doses ( >1500 mg/day), typically from prescription formulations. As uncertainty remains regarding the safety of omega-3 dietary supplements, we conducted a secondary meta-analysis restricted to trials using dietary supplements to examine their association with incident AF risk.
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Abuknesha et al. (2026) conducted a meta-analysis in Atrial Fibrillation (n=25,692). Omega-3 Fatty Acid Dietary Supplementation was evaluated on Incident atrial fibrillation.
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