Why the study?
The coexistence of biventricular hypertrophy with dynamic LV outflow tract obstruction in hypertrophic cardiomyopathy represents an unusual morphological presentation requiring detailed evaluation.
Does SARS-CoV-2 infection alter cerebral thrombus composition and clinical outcomes in patients with acute ischemic stroke undergoing mechanical thrombectomy?
Case-Control (n=12)
Yes
Does SARS-CoV-2 infection alter cerebral thrombus composition and clinical outcomes in patients with acute ischemic stroke undergoing mechanical thrombectomy?
Absolute Event Rate: 5% vs 0%
p-value: p=0.004
In patients with acute ischemic stroke, concurrent COVID-19 infection is associated with worse early neurological deficits, poorer 90-day functional outcomes, and a highly disorganized cerebral thrombus ultrastructure.
Hypertrophic cardiomyopathy (HCM) is characterized by unexplained myocardial hypertrophy and marked phenotypic heterogeneity. Although left ventricular (LV) hypertrophy is the hallmark of the disease, right ventricular (RV) involvement resulting in biventricular hypertrophy has also been reported. The coexistence of biventricular hypertrophy with dynamic LV outflow tract (LVOT) obstruction represents an unusual morphological presentation. A 48-year-old man presented with a 6-month history of exertional chest pain and dyspnea. Transthoracic echocardiography demonstrated asymmetric septal hypertrophy with systolic anterior motion of the mitral valve and a peak LVOT gradient of 40 mmHg. RV hypertrophy was also noted. Speckle-tracking echocardiography revealed reduced LV global longitudinal strain (−13.5%) with preserved RV strain. Cardiac magnetic resonance (CMR) confirmed biventricular hypertrophy and focal myocardial fibrosis. This case highlights the value of multimodality imaging, including strain echocardiography and CMR, in evaluating this uncommon phenotypic expression of HCM.
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Sridevi et al. (2026) conducted a case-control in Acute ischemic stroke with large vessel occlusion (n=12). SARS-CoV-2 infection vs. COVID-19-negative matched controls was evaluated on 90-day modified Rankin scale (mRS) (p=0.004).
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