Key result
Renal denervation-based multimodal therapy is linked to ~90% fewer monthly ICD therapies in refractory electrical storm.
Why the study?
Ventricular electrical storm is a life-threatening arrhythmia and the potential role of renal denervation in patients with ablation-refractory ES is not well established.
Does multimodal therapy including renal denervation reduce ICD therapies in patients with ablation-refractory ventricular electrical storm?
Cohort (n=10)
No
Does multimodal therapy including renal denervation reduce ICD therapies in patients with ablation-refractory ventricular electrical storm?
Multimodal therapy incorporating renal denervation represents a potentially viable adjunctive strategy for reducing ICD therapies in patients with ablation-refractory ventricular electrical storm.
May support adjunctive renal denervation in refractory electrical storm; extends small series but leaves open randomized confirmation.
Background: Ventricular electrical storm (ES) is a malignant arrhythmia that seriously threatens the patients' life. Renal denervation (RDN) has been described as a treatment modality for refractory ventricular arrhythmias. This study aims to explore the potential role in patients with ablation-refractory ES. Methods: This single-center retrospective cohort study included patients with refractory ES who underwent RDN between 2023 and 2024 with a follow-up period for 2-6 months. Implantable cardioverter defibrillator (ICD) programming results and intraoperative parameters were collected. Patients' clinical examination results were also compiled. Results: The study involved 10 patients with a mean age of 57.9 ± 7.4 years, including 4 (40%) ischemic cardiomyopathy, 6 (60%) dilated cardiomyopathy and 6 (60%) hypertension. ICD therapies showed a decreasing trend after multimodal therapy including RDN [pre-RDN 22 [9.3, 41], post-RDN 2.5 [0, 26.3]]. ICD shock therapies exhibited a similar descending tendency [pre-RDN 8.5 [1, 12.8] and post-RDN 0.5 [0, 3.5]]. Echocardiography and plasma results remained unchanged before and after surgery, including ejection fraction, left ventricular end-systolic diameter, left ventricular end-diastolic diameter, and creatinine concentration. Conclusion: Multimodal therapy including RDN may has the potential to contribute to decrease ICD therapies for patients with ES. Larger sample investigations may further demonstrate the efficacy and safety of RDN.
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Zhu et al. (2026) conducted a cohort in Refractory ventricular electrical storm (n=10). Renal denervation (RDN) vs. Pre-intervention baseline was evaluated on Monthly implantable cardioverter defibrillator (ICD) therapies. Multimodal therapy including renal denervation was associated with a reduction in median monthly ICD therapies from 3.0 pre-intervention to 0.3 post-intervention in patients with refractory electrical storm.
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