Key result
Resection of cardiac paraganglioma with rare SDHC mutation leads to LVH regression without recurrence.
Why the study?
Cardiac paragangliomas are rare primary cardiac tumors that pose diagnostic challenges and require specific preoperative management due to hormonal activity.
Case Report (n=1)
This case highlights the role of multimodality imaging, careful pre-operative alpha-blockade, and genetic testing in the successful management of a rare, hormonally active cardiac paraganglioma presenting with dynamic LVOT obstruction.
May inform resection decisions in rare SDHC-mutated cardiac paragangliomas; leaves open durability of LVH regression in larger cohorts.
Background: Cardiac paragangliomas are rare neoplasms, comprising only 1%-3% of primary cardiac tumours, and often pose a diagnostic challenge. Case Summary: A 56-year-old male presented with persistent chest pressure, palpitations and diaphoresis. Cardiac catheterization and further imaging revealed the presence of a fluorodeoxyglucose-avid enhancing epicardial mass accompanied by elevated serum catecholamines. Treatment with doxazosin followed by surgical resection was performed, confirming the diagnosis of cardiac paraganglioma on pathology. Discussion: Whilst rare, cardiac paragangliomas can be hormonally active and symptomatic, necessitating operative management. Accurate differentiation from similar masses on imaging aids in guiding preoperative hormonal evaluations and medical management, as well as in conducting genetic testing to identify causative mutations and assess heritability.
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Bhalla et al. (2026) conducted a case report in Cardiac paraganglioma (n=1). Surgical resection and alpha-blockade (doxazosin) was evaluated on Clinical outcome post-surgical resection. Surgical resection of a cardiac paraganglioma in a 56-year-old man with a rare SDHC mutation resulted in regression of left ventricular hypertrophy and no tumor recurrence at 6 months.
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