Key result
Multimodal imaging successfully identifies a rare right ventricular bony mass in a cynomolgus monkey.
Case Report (n=1)
No
This case highlights the utility of antemortem MRI and multimodality imaging for diagnosing rare intracardiac ectopic ossification in non-human primates, serving as a model for detecting similar rare cardiac diseases in humans.
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Enables antemortem detection of rare intracardiac ossification in primates; extends imaging data but leaves human translation open.
Ectopic ossification is defined as bone formation at a site where no bone tissue typically exists and usually presents a trabecular bone structure. Rare cases of ectopic ossification in cardiac masses have been previously reported. In general, cardiac masses are diagnosed by echocardiography, computed tomography, and magnetic resonance imaging (MRI). MRI, in particular, has been used in studies to evaluate cardiometabolic function and tumors in various non-human primates (NHPs). Here, we report a 15-year-old male cynomolgus monkey with significant weight loss and arrhythmia observed during a routine checkup. This is the first report of a cynomolgus monkey in which a cardiac mass with bone metaplasia in the right ventricle was confirmed by echocardiography, radiography and MRI before death.
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Ito-Fujishiro et al. (2026) conducted a case report in Intracardiac bony mass (n=1). Antemortem magnetic resonance imaging was evaluated on Detection and characterization of right ventricular mass with bone metaplasia. Antemortem magnetic resonance imaging and echocardiography successfully identified a rare intracardiac bony mass in the right ventricle of a cynomolgus monkey.
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