Key result
Severe mental illness is not associated with increased mortality after protocolized primary PCI for STEMI.
Why the study?
People with severe mental illness experience significant health disparities including in cardiovascular care, and their care pathways within protocolised primary angioplasty networks for STEMI are not well characterized.
Does a diagnosis of severe mental illness (SMI) impact acute care metrics and mortality in patients presenting with a first-time STEMI treated via a protocolised primary percutaneous coronary intervention pathway?
Cohort (n=2,292)
No
Does a diagnosis of severe mental illness (SMI) impact acute care metrics and mortality in patients presenting with a first-time STEMI treated via a protocolised primary percutaneous coronary intervention pathway?
Highly protocolised primary percutaneous coronary intervention pathways provide equitable acute care and short-term survival for STEMI patients with severe mental illness, though notable disparities exist in clinical presentation and longer-term outcomes.
Protocolized STEMI pathways may equalize short-term mortality despite SMI; leaves open disparities in presentation and longer-term outcomes.
Background: People with severe mental illness (SMI) experience significant health disparities, including in cardiovascular care. This study used natural language processing (NLP), an artificial intelligence method, to investigate care pathways for SMI patients within a highly protocolised urban primary angioplasty network for ST-elevation MI (STEMI). Methods: This cohort study used NLP to extract SMI diagnoses and clinical data from free-text electronic health records, including STEMI and non-STEMI audit data. Primary outcomes included 28-day and 1-year mortality, with secondary outcomes examining pathway performance metrics and procedural data. Exploratory outcomes assessed presenting symptoms and comorbidities. Results: A total of 2,292 adults presented with first-time STEMI from 2012-2019, of whom 51 (2.2%) had recorded SMI diagnoses. No significant differences were found in mortality between SMI and non-SMI patients at 28-day and 1-year, although a non-significant trend toward higher crude mortality in SMI patients emerged at 3 years (23.5% versus 16.1%; p=0.152). Procedure metrics and timings were similar between groups. SMI patients were more likely to have presented with cardiac arrest (adjusted OR 2.48; 95% CI [1.18-5.22]; p=0.017) and had higher rates of chronic obstructive pulmonary disease (adjusted OR 2.20; 95% CI [1.00-4.83]; p=0.049). Percutaneous coronary intervention rates in SMI patients with a non-STEMI were less than their representation in the overall non-STEMI population (2.2% versus 3.3%; p=0.042). Conclusion: Highly protocolised STEMI pathways appear to provide equitable acute care for patients with SMI without excess short-term mortality. However, potential disparities emerge in longer-term outcomes and in non-STEMI treatment pathways, suggesting a need for improved secondary prevention and targeted interventions for this vulnerable population.
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Gogarty et al. (2026) conducted a cohort in ST-elevation MI (STEMI) and Severe Mental Illness (n=2,292). Severe mental illness vs. No severe mental illness was evaluated on Overall mortality (HR 0.69, 95% CI 0.37-1.30, p=0.253). Severe mental illness was not significantly associated with overall mortality following highly protocolized primary percutaneous coronary intervention for ST-elevation MI (HR 0.69).
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