Key result
Systemic hypertension is linked to ~33% higher odds of elevated CT vitreous humor attenuation.
Why the study?
The association between systemic hypertension and vitreous humor attenuation on CT, and its relationship with age, gender, and ocular morphometric parameters, was not well established.
Is systemic hypertension associated with altered vitreous humor attenuation on computed tomography?
Case-Control (n=132)
No
Is systemic hypertension associated with altered vitreous humor attenuation on computed tomography?
Systemic hypertension is associated with increased vitreous humor attenuation on cranial CT, suggesting subtle ocular microstructural alterations.
Answers are grounded in this paper and cite their sources.
Should not yet alter CT interpretation in hypertension; leaves open whether vitreous attenuation reflects clinically relevant ocular changes.
Aims: To investigate the association between systemic hypertension and vitreous humor attenuation on computed tomography (CT), and to evaluate its relationship with age, gender, and ocular morphometric parameters. Methods: This retrospective comparative study included 132 participants (66 hypertensive patients and 66 age- and sex-matched controls) who underwent cranial CT between January 2023 and March 2026. Vitreous attenuation values were measured using region-of-interest (ROI) analysis, and ocular globe dimensions (anteroposterior and transverse diameters) were assessed on axial images. Statistical analyses were performed using non-parametric tests, and correlations were evaluated with Spearman’s coefficient. Univariate and multivariate logistic regression analyses were used to assess factors associated with hypertension. Results: Vitreous attenuation values were significantly higher in the hypertensive group compared to controls (mean: 12.44±2.3 vs. 11.16±1.8 Hounsfield Units, p=0.004). No significant differences were observed in ocular globe dimensions between groups (p>0.05). A significant positive correlation was found between age and vitreous attenuation in both hypertensive (r=0.332, p=0.006) and control groups (r=0.411, p=0.001), while no association was identified between age and globe dimensions. No sex-related differences were detected. In multivariate analysis, mean vitreous attenuation remained significantly associated with hypertension (OR=1.333, 95% CI: 1.101-1.614, p=0.003). Additionally, mean anteroposterior (AP) diameter demonstrated a significant inverse association with hypertension in the multivariable model (OR=0.421, 95% CI: 0.181-0.976, p=0.044). Conclusion: Systemic hypertension is associated with increased vitreous attenuation on CT, suggesting subtle microstructural alterations. These findings suggest a possible relationship between systemic hypertension and vitreous attenuation.
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Çapkan et al. (2026) conducted a case-control in Systemic hypertension (n=132). Systemic hypertension vs. Normotensive controls was evaluated on Mean vitreous humor attenuation on computed tomography (Hounsfield Units) (OR 1.333, 95% CI 1.101-1.614, p=0.003). Systemic hypertension was associated with significantly increased vitreous humor attenuation on computed tomography compared to normotensive controls (OR 1.333).
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