Successful repeat carotid artery replacement using vascular grafts in a case with recurrent dedifferentiated liposarcoma: a case report

Q: What is the clinical evidence from this study?

Study design: Case Report. Population: Recurrent dedifferentiated liposarcoma (n=1). Intervention: Repeat carotid artery replacement using a vascular graft.

Q: What does this research mean for the field?

Repeat carotid artery replacement using a vascular graft combined with adjuvant radiotherapy is feasible and can achieve sustained local disease control in patients with recurrent dedifferentiated liposarcoma. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Ayano Tamura; Ryuhei Okada; Ryo Wakejima; Susumu Kirimura; Kazuchika Ohno; Toshifumi Kudo; Kentaro Tanaka; Kenichi Okubo; Takahiro Asakage

doi:10.1093/jscr/rjag837

August 31, 2026Journal of Surgical Case ReportsOpen Access

Successful repeat carotid artery replacement using vascular grafts in a case with recurrent dedifferentiated liposarcoma: a case report

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Key result

Repeat carotid replacement plus radiotherapy maintains recurrence-free local control for ~2 years in recurrent liposarcoma.

n=1

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Why the study?

Dedifferentiated liposarcoma is prone to local recurrence and complete resection remains the treatment of choice, but management of recurrent cases involving carotid artery replacement is not well established.

Key Points

To assess the feasibility of repeat carotid artery replacement using a prosthetic vascular graft for locally recurrent dedifferentiated liposarcoma.
Treated a 70-year-old man presenting with recurrent dedifferentiated liposarcoma invading the right common carotid and subclavian arteries.
Performed initial en bloc resection with T-shaped prosthetic vascular graft reconstruction followed by postoperative radiotherapy (60 Gy in 30 fractions).
Conducted repeat en bloc resection and carotid reconstruction using a 6-mm heparin-bonded graft upon local recurrence at the arterial anastomosis 2 years and 7 months later, followed by adjuvant radiotherapy (60 Gy in 24 fractions).
The patient was discharged on postoperative Day 9 following repeat surgery without new neurological deficits or vascular graft complications.
Achieved durable local disease control, with the patient remaining alive and recurrence-free for 2 years and 3 months (more than 2 years) after the final operation.

Study Design

Type

Case Report (n=1)

Multicenter

No

Structured PICO

P

Population

A 70-year-old man with recurrent dedifferentiated liposarcoma invading the right common carotid and subclavian arteries, treated and followed for over 2 years.

I

Intervention

En bloc tumor resection with repeat carotid artery replacement using a prosthetic vascular graft (heparin-bonded graft) and postoperative adjuvant radiotherapy.

O

Outcome

Recurrence-free survival and postoperative neurological status

Repeat vascular graft replacement for the carotid artery may be a feasible and effective local control strategy for selected patients with recurrent dedifferentiated liposarcoma invading major cervical vessels.

Limitations

Single patient case report

Implication

May support repeat carotid reconstruction in select recurrent liposarcoma cases; leaves open broader applicability and prospective validation.

Abstract

Dedifferentiated liposarcoma is prone to local recurrence, and complete resection remains the treatment of choice. We report a 70-year-old man who underwent carotid artery replacement with vascular grafts on two occasions for recurrent disease. A recurrent tumor invading the right common carotid and subclavian arteries was resected with vascular graft replacement. After 2 years and 7 months, recurrence developed around the carotid artery anastomosis. En bloc tumor resection with repeat carotid artery replacement using a prosthetic vascular graft was successfully performed. The patient was discharged on postoperative Day 9 without postoperative neurological deficits. Postoperative radiotherapy was administered following both operations. He remains free of recurrence more than 2 years after the most recent surgery. This case suggests that repeat carotid artery replacement using a vascular graft may be a feasible treatment option for selected patients with recurrent dedifferentiated liposarcoma.

Discussion

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Cite This Study

Tamura et al. (2026) conducted a case report in Recurrent dedifferentiated liposarcoma (n=1). Repeat carotid artery replacement using a vascular graft was evaluated. Repeat carotid artery replacement using a vascular graft and radiotherapy provided effective local control without recurrence for over 2 years in a patient with recurrent liposarcoma.

synapsesocial.com/papers/6ad0fd263afa093ea9ad021b https://doi.org/10.1093/jscr/rjag837

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Successful repeat carotid artery replacement using vascular grafts in a case with recurrent dedifferentiated liposarcoma: a case report

Figures

Key Points

Study Design

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

Successful repeat carotid artery replacement using vascular grafts in a case with recurrent dedifferentiated liposarcoma: a case report

Figures

Key Points

Study Design

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

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