Key result
Pulsed field ablation for SVC isolation can induce sinus node artery spasm and delayed sinus arrest.
Why the study?
The effects of pulsed field ablation on adjacent structures including the sinus node and its arterial supply remain incompletely understood.
Case Report (n=1)
This case highlights the risk of delayed sinus arrest due to sinus node artery spasm after pulsed field ablation near the superior vena cava.
Caution for delayed sinus arrest after PFA SVC isolation; leaves open true incidence and prevention strategies.
Background: Pulsed field ablation (PFA) has emerged as a novel non-thermal ablation modality with preferential myocardial selectivity. However, its effects on adjacent structures, including the sinus node and its arterial supply, remain incompletely understood. Case summary: A 72-year-old woman underwent repeat ablation for recurrent paroxysmal atrial fibrillation. Following pulmonary vein isolation, superior vena cava (SVC) isolation was performed using a PFA system. Sinus rhythm was initially preserved. However, sinus arrest developed several minutes after ablation. High right atrial backup pacing was initiated. Coronary angiography revealed severe spasm of the sinus node artery. Sinus node function gradually recovered after supportive management. Post-procedural voltage mapping confirmed successful SVC isolation. Discussion: This case highlights delayed sinus arrest following SVC isolation using PFA, with angiographic evidence suggesting sinus node artery spasm. While multiple mechanisms may contribute to sinus node dysfunction after PFA, coronary vasospasm should be considered, particularly in cases with delayed onset.
No takes yet. Share an insight, caveat, or question.
Hojo et al. (2026) conducted a case report in Recurrent paroxysmal atrial fibrillation (n=1). Pulsed field ablation (PFA) was evaluated on Development of sinus arrest (Safety outcome). Pulsed field ablation for superior vena cava isolation induced transient coronary spasm of the sinus node artery, leading to delayed sinus arrest.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: