Key result
Hispanic ethnicity linked to ~90% higher odds of recurrent VTE at 90 days.
Why the study?
Hispanic patients are underrepresented in VTE cohorts and their 90-day post-diagnosis outcomes remain incompletely characterized.
Does Hispanic ethnicity affect the 90-day risk of recurrent VTE, major bleeding, or mortality in adults with acute VTE compared to non-Hispanic ethnicity?
Cohort (n=7,168)
Yes
Does Hispanic ethnicity affect the 90-day risk of recurrent VTE, major bleeding, or mortality in adults with acute VTE compared to non-Hispanic ethnicity?
Odds Ratio: 1.9 (95% CI 1.1–3.28)
Absolute Event Rate: 1.6% vs 1.2%
In patients with acute VTE, Hispanic ethnicity is associated with modestly higher relative odds of recurrent VTE and major bleeding at 90 days compared to non-Hispanic ethnicity, although the absolute differences are small.
Hispanic ethnicity was associated with higher adjusted odds of recurrent VTE and major bleeding; leaves open whether ethnicity should inform VTE management strategies.
Background Racial and ethnic differences in venous thromboembolism (VTE) incidence have been reported, but Hispanic patients remain underrepresented in VTE cohorts, and their 90-day post-diagnosis outcomes remain incompletely characterized. Objective To compare 90-day risks of recurrent VTE, major bleeding, and mortality between Hispanic and non-Hispanic patients with acute VTE. Design, Setting, and Participants Exposure-matched analysis of the RIETE registry, a prospective, international cohort of adults with acute VTE. Hispanic patients were matched 1:3 to non-Hispanic patients by age, sex, index VTE phenotype, active cancer, and calendar period. The matched cohort included 1,792 Hispanic and 5,376 non-Hispanic patients. Exposure Self-identified Hispanic ethnicity. Main Outcomes and Measures Ninety-day recurrent VTE, major bleeding, and all-cause mortality. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated using hierarchical logistic regression. Results The matched cohort had a mean age of 57±18 years, and 59% were women. At 90 days, recurrent VTE occurred in 1.6% of Hispanic patients and 1.2% of non-Hispanic patients (absolute difference 0.4 percentage points); major bleeding occurred in 2.1% and 1.7%, respectively (absolute difference 0.4 percentage points); the composite outcome occurred in 3.4% and 2.9%, respectively (absolute difference, 0.5 percentage points); and mortality occurred in 4.1% and 3.9%, respectively (absolute difference,0.2 percentage points). In fully adjusted models, Hispanic ethnicity was associated with increased odds of recurrent VTE (OR 1.90; 95% CI, 1.10 – 3.28), major bleeding (OR 1.73; 95% CI, 1.09 – 2.75), and the composite outcome (OR 1.77; 95% CI, 1.23 – 2.54), but not mortality (OR 1.05; 95% CI, 0.68 – 1.64). Conclusions and Relevance In this matched registry analysis, self-identified Hispanic ethnicity was associated with modestly higher adjusted odds of recurrent VTE and major bleeding, but not mortality. Although adjusted relative estimates differed, absolute differences were small. These observational associations should not be interpreted as causal because residual confounding cannot be excluded.
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Cabrera et al. (2026) conducted a cohort in Acute venous thromboembolism (VTE) (n=7,168). Self-identified Hispanic ethnicity vs. Non-Hispanic ethnicity was evaluated on 90-day recurrent VTE (OR 1.90, 95% CI 1.10-3.28). In adults with acute VTE, self-identified Hispanic ethnicity was associated with increased odds of recurrent VTE (OR 1.90; 95% CI 1.10-3.28) and major bleeding at 90 days, but not mortality.
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