Key result
Tau20-RETROmapping system feasibility for guiding non-pulmonary vein driver ablation in AF remains unproven.
Why the study?
Pulmonary vein isolation is ineffective in a significant proportion of patients with atrial fibrillation, necessitating methods to identify non-PV drivers of AF.
This abstract outlines the feasibility testing of a novel combined stimulator-recording system (Tau20-RETROmapping) designed to identify and target non-pulmonary vein drivers in patients with atrial fibrillation.
Answers are grounded in this paper and cite their sources.
ET-GP mapping with Tau20-RETROmapping is feasible in sinus rhythm; leaves open whether targeting these sites improves PVI outcomes.
Pulmonary vein isolation (PVI) is ineffective in a significant proportion of patients with atrial fibrillation (AF). The Tau20-RETROmapping system (TauRhythm Therapies, UK) is a combined stimulator-recording system designed to interrogate the atria for non-PV drivers of AF. This novel investigational device can be used in sinus rhythm to identify ectopy-triggering ganglionated plexi (ET-GP) or to interpret activation maps of organized wavefronts during AF. We tested the feasibility of applying both approaches in the same patient to guide ablation.
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Kanagaratnam et al. (2026) studied Atrial fibrillation (AF). Tau20-RETROmapping system guided ablation was evaluated on Feasibility. The feasibility of using the Tau20-RETROmapping system to guide ablation of non-pulmonary vein drivers in patients with atrial fibrillation was evaluated, though no results were reported.
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