Key result
This preclinical study compared lesion depths and microbubble formation between Sequence 2 and Sequence 1 pulse recipes for the variable loop-circular pulsed field ablation catheter.
Why the study?
The impact of Sequence 2 pulse recipe on lesion efficacy and microbubble formation during pulsed field ablation with the variable loop-circular catheter has not been characterized.
Does Sequence 2 (Seq2) preserve lesion depths and affect microbubble formation compared to Sequence 1 (Seq1) during pulsed field ablation in a preclinical model?
Does Sequence 2 (Seq2) preserve lesion depths and affect microbubble formation compared to Sequence 1 (Seq1) during pulsed field ablation in a preclinical model?
This study aims to characterize whether a faster Sequence 2 pulse recipe for variable loop-circular PFA catheters preserves lesion depth and alters microbubble formation compared to Sequence 1.
Waveform design is central to lesion formation during pulsed field ablation (PFA). Sequence 2 (Seq2), a recently introduced pulse recipe for the variable loop-circular PFA catheter (VLCC), substantially reduces ablation delivery time while aiming to preserve lesion efficacy. However, its impact on lesion efficacy and microbubble formation has yet to be characterized. This study describes Seq2 optimization and compares lesion depths and microbubble formation with Sequence 1 (Seq1).
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Biase et al. (2026) studied this question. Sequence 2 (Seq2) pulse recipe for variable loop-circular PFA catheter vs. Sequence 1 (Seq1) was evaluated on lesion depths and microbubble formation. This preclinical study compared lesion depths and microbubble formation between Sequence 2 and Sequence 1 pulse recipes for the variable loop-circular pulsed field ablation catheter.
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