Key result
A computational model incorporating PIEZO1 voltage-modulated gating provides a valuable framework for evaluating mechanically induced cardiac excitation, though it currently relies on kinetic data from non-cardiac cells.
This commentary highlights a novel computational model demonstrating that PIEZO1 channels can theoretically initiate cardiac mechanical capture, while emphasizing the critical need for species-specific physiological data to refine future electromechanical models.
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Cai et al. (2026) conducted an editorial in Cardiac electromechanical pacing. PIEZO1 computational modeling was evaluated. A computational model incorporating PIEZO1 voltage-modulated gating provides a valuable framework for evaluating mechanically induced cardiac excitation, though it currently relies on kinetic data from non-cardiac cells.
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