Key result
Despite preserved ventricular function on conventional echocardiography, 62% of Group B and 36% of Group C children with acute rheumatic fever and severe carditis ultimately required surgery during a one-year follow-up.
Normal ejection fraction at presentation in severe pediatric rheumatic carditis may falsely reassure, highlighting the potential need for global longitudinal strain and NT-proBNP to better predict disease trajectory and surgical risk.
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Murtaza Kamal (2026) conducted a letter in Acute rheumatic fever and severe carditis (n=100). Conventional echocardiography (ejection fraction and fractional shortening) vs. Global longitudinal strain and NT-proBNP (proposed) was evaluated on Requirement for surgery. Despite preserved ventricular function on conventional echocardiography, 62% of Group B and 36% of Group C children with acute rheumatic fever and severe carditis ultimately required surgery during a one-year follow-up.
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