Key result
Aggregate discordant aortic stenosis was not associated with a significant difference in 1-year mortality compared to concordant high-gradient AS (13.1% vs 11.9%; adjusted HR 1.19, p=0.08), though underlying low-flow phenotypes carried higher risk.
Hazard Ratio: 1.19
Absolute Event Rate: 13.1% vs 11.9%
p-value: p=0.08
A flow-centered paradigm grounded in stroke volume index (SVi) may better align anatomical staging with physiological risk in advanced aortic stenosis.
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Ashish H. Shah (2026) conducted a letter in Aortic stenosis (n=15,233). Discordant aortic stenosis (including low-gradient AS) vs. Concordant high-gradient aortic stenosis was evaluated on 1-year mortality (HR 1.19, p=0.08). Aggregate discordant aortic stenosis was not associated with a significant difference in 1-year mortality compared to concordant high-gradient AS (13.1% vs 11.9%; adjusted HR 1.19, p=0.08), though underlying low-flow phenotypes carried higher risk.
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