Key result
Combining adaptive pragmatic trials with registries is essential to overcome evidence gaps in cardiogenic shock.
Examines trial design and evidence generation in cardiogenic shock, highlighting adaptive platforms and registry integration to improve patient survival.
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Lalani et al. (2026) conducted an editorial in Cardiogenic shock. An integrated evidence ecosystem combining adaptive, pragmatic randomized clinical trials and dedicated observational registries is essential to address the high mortality and treatment heterogeneity in cardiogenic shock.
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