Key result
Werner syndrome is linked to an ~18-point lower Hepatic Steatosis Index than insulin-resistant diabetes before BMI adjustment.
Why the study?
The characteristics and appropriate indices for estimating dyslipidemia and fatty liver associated with Werner syndrome in Japan were not well described.
Cross-Sectional (n=149)
Yes
Absolute Event Rate: 22.7% vs 41.1%
p-value: p=< 0.0001
HSI differences in Werner syndrome appear BMI-mediated; leaves open need for syndrome-specific steatosis thresholds in low-BMI progeria.
For the purpose of examining the characteristics of dyslipidemia and fatty liver in patients with Werner syndrome in Japan in recent years, we searched all case reports of Japanese Werner syndrome reported on Medical Online and PubMed since 1996, and collected and examined the data and clinical features described in these reports. In addition, as there are few descriptions of treatment methods in these reports from Medical Online and PubMed, we analyzed 12 cases for which detailed data on treatment methods are available at Chiba University. Geriatr Gerontol Int 2021; 21: 133-138.
No takes yet. Share an insight, caveat, or question.
Tsukamoto et al. (2020) conducted a cross-sectional in Werner syndrome and Metabolic dysfunction-associated steatotic liver disease (MASLD) (n=149). Werner syndrome vs. Insulin-resistant type 2 diabetes was evaluated on Hepatic steatosis index (HSI) (p=< 0.0001). Individuals with Werner syndrome had a significantly lower Hepatic Steatosis Index compared to those with insulin-resistant type 2 diabetes (22.7 vs 41.1, p < 0.0001), though the difference became non-significant after adjusting for BMI.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: