Perinatal transmission and cure of extensively drug-resistant tuberculosis in an infant

Study synopsis We describe a rare case of perinatally acquired extensively drug-resistant tuberculosis in an infant. The infant was successfully treated with an individualised all-oral multidrug regimen containing delamanid, a drug rarely described in the treatment of perinatal tuberculosis. What the study adds. This brief report offers insight into a clinical case of perinatally acquired extensively drug-resistant tuberculosis (XDR-TB), and outlines the individualised treatment plan that led to a successful treatment outcome. Implications of the findings. The report highlights the need for evidence-based guidance on XDR-TB in this paediatric population, as well as further research on preventive strategies for mitigating mother-to-child transmission of TB.