Allogeneic stem cell transplantation represents the only curative treatment for thalassemia major. In this perspective article, Drs. Angelucci and Baronciani, who pioneered this therapeutic approach collaborating with Guido Lucarelli in Pesaro, Italy, discuss how allogeneic stem cell transplantation has changed the natural history of thalassemia major. See related article on page 1859.
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Angelucci et al. (2008) studied this question.
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