Key result
Brain-heart axis dysregulation drives cardiovascular disease progression and emerges as a key translational therapeutic target.
Why the study?
Disruption of the brain-heart axis regulatory homeostasis plays a pivotal role in cardiovascular diseases, but its core mechanisms and translational applications require systematic examination.
Highlights brain-heart axis in CVDs; leaves open targeted therapies pending prospective trials.
The brain-heart axis, a core bidirectional communication network linking the central nervous system and cardiovascular system, plays a pivotal role in the onset, progression, and prognosis of cardiovascular diseases when its regulatory homeostasis is disrupted. This review systematically examines the core regulatory pathways and molecular mechanisms of the brain-heart axis and highlights its pathological roles in major cardiovascular diseases, such as hypertension, coronary artery disease, heart failure, and arrhythmias. Particular emphasis is placed on recent advances in key pathways, including autonomic imbalance, hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis, and dysregulation of neuroimmune and inflammatory responses. In parallel, this review explored translational pathways for clinical applications, including neurostimulation therapies, psychological intervention strategies, biomarker development, and personalized diagnostic and therapeutic protocols. By integrating mechanistic insights with translational perspectives, this article aims to provide a theoretical foundation for elucidating neurogenic mechanisms in cardiovascular disease and practical guidance for developing innovative precision-based diagnostic and therapeutic strategies.
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Tian et al. (2026) conducted a review in Cardiovascular diseases. The brain-heart axis plays a pivotal role in the onset and progression of major cardiovascular diseases, with recent advances highlighting potential translational pathways for clinical applications.
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