Two series of pyridazinone derivatives (19-34) were synthesized and evaluated for antitubercular activities against Mycobacterium tuberculosis H 37 Rv strain.The results illustrated that among the synthesized compounds, compound 25, 5-(4-hydroxy-3-methoxybenzyl)-3-(4-chloro-phenyl)-1,6-dihydro-6-pyridazinone emerged as a lead compound with good antitubercular activity.Four more compounds, (21, 22, 29 & 33) were significant in their antitubercular action.
No takes yet. Share an insight, caveat, or question.
Husain et al. (2011) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: