Comment on “Duration of antibiotic therapy: with or without biomarkers?”: applying the double-trigger approach at the bedside

Antimicrobial resistance has emerged as a critical global health challenge.Significant variability in antibiotic prescribing practices underscores the urgent need for high-quality evidence to inform optimal antibiotic prescribing policies.The ideal duration of antimicrobial therapy remains uncertain, and a one-size-fits-all approach is far from ideal.In this review, we examine bacterial growth kinetics and antibiotic pharmacodynamics and explore various strategies for determining the duration of antibiotic therapy: fixed duration, biomarker-guided, clinical course-based, and the more recent double-trigger approach.