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October 15, 2026Clinical & Experimental Allergy

Plasma Resolvin D2 Is Elevated and Lipoxin A 4 Is Reduced in Atopic Dermatitis: A Candidate Lipid Mediator Imbalance

Maho Tagui Keisuke Shimizu Koremasa Hayama Yoshimi Miki Shota Toyoshima Mana Ito Hideki Fujita Yoshitaka Taketomi Makoto Murakami Yoshimichi Okayama

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Abstract

Summary Plasma lipid mediators are broadly suppressed in atopic dermatitis, except resolvin D2, which is elevated. Lipoxin A 4 is reduced in atopic dermatitis and warrants investigation as an anti‐inflammatory target.

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Cite This Study

Tagui et al. (2026) studied this question.

synapsesocial.com/papers/6ad3104e709cd65f49745f5a https://doi.org/10.1111/cea.70455

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1The causal relationship and potential mediators between plasma lipids and atopic dermatitis: a bidirectional two-sample, two-step mendelian randomization2024 · 7 citations
2PO54 | Resolvin response in bronchial asthma patients: endotype and clinical severity2025
3Resolvin D1 and Its Precursor Docosahexaenoic Acid Promote Resolution of Adipose Tissue Inflammation by Eliciting Macrophage Polarization toward an M2-Like Phenotypepreclinical · 2011 · 419 citations
4From lipid switch to tissue repair: how resolvins reprogram macrophage polarization and functionOriginal Research · 2026 · 2 citations
5Development and Validation of Methodologies for the Identification of Specialized Pro-Resolving Lipid Mediators and Classic Eicosanoids in Biological Matrices2024 · 15 citations

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Adiposity associates with lower plasma resolvin E1 (Rve1): a population study2024
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