Why the study?
Chronic lead exposure causes sustained hypertension potentially via reactive oxygen species and oxidative DNA damage, but the role of vitamin C supplementation is unclear.
Does vitamin C supplementation ameliorate lead-induced hypertension and oxidative damage in male Wistar rats?
Does vitamin C supplementation ameliorate lead-induced hypertension and oxidative damage in male Wistar rats?
Vitamin C supplementation effectively prevents lead-induced hypertension and oxidative DNA damage in a rat model, supporting the pathogenic role of reactive oxygen species.
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Feng et al. (2026) studied lead-induced hypertension. Vitamin C vs. Lead acetate alone was evaluated on Blood pressure, antioxidants, total antioxidant status, NO metabolites, MDA, and 8-hydroxy 2-deoxyguanosine.
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