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January 1, 1990The Journal of AntibioticsOpen Access

Chemical and biological properties of rubiginone, a complex of new antibiotics with vincristine-cytotoxicity potentiating activity.

MASAHISA OKA Hideo Kamei Yasutaro Hamagishi Koji Tomita Takeo Miyaki MASATAKA KONISHI TOSHIKAZU OKI

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Abstract

A novel complex of isotetracenone (angucyclinone) group antibiotics was discovered from the cultured broth of Streptomyces griseorubiginosus No. Q144-2. The antibiotic consisted of six related factors, designated rubiginones A1, A2, B1, B2, C1 and C2. They significantly potentiated cytotoxicity of vincristine (VCR) against VCR-resistant P388 leukemia and Moser cells.

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OKA et al. (1990) studied this question.

synapsesocial.com/papers/6ad3b59acffe54d1857d1ce8 https://doi.org/10.7164/antibiotics.43.967

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