Drug-induced liver injury presents with extremely diverse histologic patterns, including necroinflammatory, cholestatic, steatotic and vascular patterns. Sinusoidal obstruction syndrome (SOS), also referred to as toxic sinusoidal injury, veno-occlusive disease or blue liver syndrome, is a commonly recognized vascular pattern of drug-induced liver injury,1 and has been frequently associated with oxaliplatin-based chemotherapy.2,3,4,5,6 In this issue, we present a case of SOS after 6 cycles of oxaliplatin-based preoperative chemotherapy for colorectal cancer liver metastasis and discuss the morphologic findings of SOS.
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Seo et al. (2014) studied this question.
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