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January 1, 1991Chemical and Pharmaceutical BulletinOpen Access

Formation of pyrazine derivatives from D-glucosamine and their deoxyribonucleic acid(DNA) strand breakage activity.

Kunihiro Sumoto Yumiko Nakashima

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Abstract

Two pyrazine derivatives [fructosazine (3) and deoxyfructosazine (6)] were simultaneously formed in a solution of D-glucosamine hydrochloride under various conditions. They showed deoxyribonucleic acid (DNA) strand breakage activity in plasmid pBR322 comparable to that of D-glucosamine. The DNA strand breakage by fructosazine (3) was stimulated by Cu2+.

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Sumoto et al. (1991) studied this question.

synapsesocial.com/papers/6ad3e22a5b703ac138ef670e https://doi.org/10.1248/cpb.39.792

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