Why the study?
Insulin resistance plays a central role in the pathogenesis of type 2 diabetes and its fundamental mechanisms in the development of cardiometabolic complications require comprehensive analysis.
The paper underscores the necessity of transitioning from a glucocentric to a cardiocentric management model in type 2 diabetes, focusing on the central role of insulin resistance in cardiovascular pathogenesis.
Ushbu tadqiqot 2-tip qandli diabet (2-TQD) patogenezida markaziy o‘rin tutuvchi insulin rezistentligi (IR) va uning kardiometabolik asoratlar rivojlanishidagi fundamental mexanizmlarini kompleks tahlil qilishga bag‘ishlangan. Maqolada IR shunchaki glikemik profilning buzilishi emas, balki qon tomir endoteliysi darajasidagi chuqur molekulyar disfunksiya ekanligi ilmiy asoslab berilgan. Tadqiqot davomida insulin signalining o‘tkazilish yo‘llari — vazoprotektiv va proaterogen kaskadlar o‘rtasidagi nomutanosiblikning endotelial NO-sintaza faoliyatiga ta’siri ko‘rib chiqildi. Muallif tomonidan IR fonida rivojlanuvchi surunkali tizimli yallig‘lanish va oksidativ stressning miokardial remodeling hamda aterosklerotik blyashkalar destabilizatsiyasidagi o‘rni ochib berilgan.
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Karimova et al. (2026) conducted a review in Type 2 diabetes mellitus. Insulin resistance was evaluated.
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