Large-Scale Repository Design

The design and implementation of a large-scale biologic repository is typically an exercise in converting a basic warehouse-type building into a highly sophisticated storage facility. A model for a repository with infrastructure to accommodate 100 units for subambient temperature storage is utilized. We present an outline of the design process and considerations, timelines, and a cost model. Included are guides for determining the floor space required, and recommendations for establishing engineering design features. Our model projects a 7000-square foot facility, requiring 6 to 8 months to design and build, uses 30 freezer units at start-up, with an initial cost of $1.5 to $2.5 million.