The use of isotope pattern deconvolution analysis is proposed to simplify the double spiking species-specific isotope dilution result calculations when inter-conversion might occur. A detailed example is given for the determination of Cr(III)/Cr(VI) in yeast by isotope dilution-HPLC-ICP-MS. The results are in exact agreeent with the conventional isotope dilution calculations.
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Meija et al. (2006) studied this question.
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