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It is advisable to conduct a comprehensive study of the morphological assessment of the expression of endometrial estrogen and progesterone receptors, inflammatory markers in the second phase of the menstrual cycle in patients with impaired reproductive function (infertility, miscarriage, failed IVF attempts). The optimal period for investigation of endometrial dysfunction via endometrial biopsy is the second phase of the cycle (the period of “implantation window”). Creating a diagnostic algorithm, histological and immunohistochemical studies in the endometrial dysfunction will allow to justify the optimal choice of therapy.
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Tolibova et al. (2015) studied this question.
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