Multi‐Scale Magnetically Controlled Soft Matter Robots for Tissue Interfacing Applications

Magnetically controlled soft matter robots (MSMRs) integrate remote magnetic control with soft matter adaptability, providing a promising platform for minimally invasive biomedical tasks at tissue interfaces across multiple scales. Although magnetic manipulability enables remote positioning of MSMRs, the intrinsic properties of soft materials are equally critical to their task‐specific performance at tissue interfaces, given that sustained interplay between MSMRs and host tissues persists throughout the entire tissue‐interfacing workflow. Both factors jointly influence the overall biomedical performance. This review systematically elaborates the constituent soft matter and magnetic manipulation strategies of MSMRs, together with medical imaging‐based perception and sensing, as the fundamental basis for tissue interfacing applications. Besides, the interaction mechanisms between MSMRs and tissue interfaces under three distinct stages—low‐interference delivery, target‐interface coupling, and post‐coupling regulation—are thoroughly dissected. Based on the dominant configurations formed by MSMRs at target tissue interfaces during tissue interfacing biomedical interventions, MSMRs are classified into five categories, including patch, stent, embolization, swarm, and non‐retentive MSMRs. Their performance evaluations are discussed through delivery, deployment, functional output, and biosafety. Furthermore, challenges and future perspectives of MSMRs for tissue interfacing applications are also discussed.