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The deoxyribonucleic acid (DNA) of the mycoplasma Thermoplasma acidophilum has a base composition of 46 mol% guanine plus cytosine (G+C). Depurination can occur to the DNA in the culture conditions, giving rise to a product of lower buoyant density. This effect probably accounts for earlier descriptions of a much lower G+C content in the DNA. The size of the T. acidophilum genome, as measured by DNA renaturation, was 30% the size of the Escherichia coli genome.
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Searcy et al. (1975) studied this question.
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